Professor Colin Fishwick joined the staff at University of Leeds, School of Chemistry in 1985, being appointed to a Chair in Medicinal Chemistry in 2009, and Head of the School of Chemistry in 2018.
His internationally leading research is focussed on the application of structure-based computational molecular design for the rapid identification of drug leads.
A particular focus of his work is the development of new anti-infectives, particularly for treatment of infections resulting from drug resistant bacteria as well as parasites. Recent highlights include new inhibitors of metallo-beta lactamases
[Nature Comm., 2016, 7, 121406], ‘dual-targeting’ inhibitors of bacterial DNA gyrase/topoisomerases [Eur J Med Chem, 2014, 86, 31], the first small molecule inhibitors of members of the ribonuclease E family [Sci Rep, 2015, 5, 8028], inhibitors targeting bacterial seryl-tRNA synthetase [J Med Chem, 2019, 62, 21, 9703], development of selective FGFR2 Inhibitors [J Med Chem, 2022, 65, 1481], and use of adhirons to inhibit immune complex binding to Fc-gamma receptor IIIa [PNAS, 2018;115(1):E72-E81].
His research is highly multidisciplinary, with extensive collaborations with colleagues both in the UK and abroad.